Readers ask: What Does A High Folate And Low Vitamin B12 Indicate?

What does high folate and low B12 mean?

The people with low B12 and high folate levels were more likely to have anemia than did people with low B12 levels and normal folate levels. However, many of these studies were conducted in older people, a group more likely to have difficulty absorbing B12.

What medical conditions cause high folate levels?

There are several other medical conditions that may increase folic acid needs including anyone taking medications for epilepsy, Rheumatoid arthritis, lupus, psoriasis, asthma, and inflammatory bowel disease; anyone with kidney disease who is on dialysis; anyone with liver, sickle cell, or celiac diseases.

What does a high folate level mean?

High levels of folate in the blood may mean that you eat a diet rich in folate or folic acid, take vitamins, or take folic acid pills. Consuming more folate than the body needs does not cause problems. High folate levels can also mean a vitamin B12 deficiency. Body cells need vitamin B12 to use folate.

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What symptom of vitamin B12 deficiency is masked by high folate intake?

The results of the first study suggest that during vitamin B12 deficiency, high serum folate levels exacerbate (rather than mask) anemia and also exacerbate cognitive symptoms.

What are the side effects of too much folate?

Although doses up to 5 mg daily have been safely used in some research, doses of folic acid greater than 1 mg daily might cause abdominal cramps, diarrhea, rash, sleep disorders, irritability, confusion, nausea, stomach upset, behavior changes, skin reactions, seizures, gas, excitability, and other side effects.

Who should be sure to consume enough folate?

Most people in the United States get enough folate. However, certain people are more likely than others to have trouble getting enough folate: Teen girls aged 14–18 years, women aged 19–30 years, and non-Hispanic black women. People with alcohol use disorder.

How do you treat high folate levels?

A high folate intake can mask vitamin B-12 deficiency until its neurological effects become irreversible. This can typically be remedied by taking a supplement containing 100 percent of the daily value of both folic acid and vitamin B-12.

What is the normal range for folate in blood test?

Normal Results

The normal range is 2.7 to 17.0 nanograms per milliliter (ng/mL) or 6.12 to 38.52 nanomoles per liter (nmol/L). Normal value ranges may vary slightly among different labs.

What folate does to the body?

Folic acid helps make healthy red blood cells, which carry oxygen around the body. If we do not have enough folic acid, the body can make abnormally large red blood cells that do not work properly. This causes folate deficiency anaemia, which can cause tiredness and other symptoms.

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Is a high folate level bad?

“Today it’s worrisome that taking extra folate over the long term might lead to more DNA methylation, which then might lead to extra diseases including potentially an increased chance of developing cancer and other diseases of aging,” Issa said.

Can you have too much folate in your blood?

Yes, you can get too much folic acid, but only from man-made products such as multivitamins and fortified foods, such as breakfast cereals. You can‘t get too much from foods that naturally contain folate. You should not get more than 1,000 micrograms of folic acid a day, unless your doctor prescribes a higher amount.

Should I be worried if my B12 is high?

Though daily high doses of B12 are unlikely to cause harm in most people, extremely high doses should be avoided unless prescribed by a healthcare professional. If you think you may be deficient in B12, speak with your doctor, who can recommend an appropriate treatment based on your level of deficiency.

Is folate and vitamin B12 the same thing?

Vitamin B12, also called cobalamin, is found in foods from animals, such as red meat, fish, poultry, milk, yogurt, and eggs. Folate (Vitamin B9) refers to a natural occurring form of the vitamin, whereas folic acid refers to the supplement added to foods and drinks.

What is the relationship between B12 and folate?

Folic acid works closely with vitamin B12 in making red blood cells and helps iron function properly in the body. Vitamin B9 works with vitamins B6 and B12 and other nutrients in controlling the blood levels of the amino acid homocysteine.

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What are the symptoms of B12 deficiency?

Symptoms of vitamin B12 deficiency

  • a pale yellow tinge to your skin.
  • a sore and red tongue (glossitis)
  • mouth ulcers.
  • pins and needles (paraesthesia)
  • changes in the way that you walk and move around.
  • disturbed vision.
  • irritability.
  • depression.

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